Existing Drugs Reverse Alzheimer’s in Mice : With increasing age, the memory-related disease Alzheimer’s or associated dementia affects a large population of elderly people worldwide. According to an estimate, about 25 million people worldwide are suffering from this disease. There is no exact cause nor cure for this disease so far. In such a situation, research is going on continuously regarding this disease. In this list, lead researcher of Structural Bioinformatics & Networks based in Barcelona, Spain Dr. Patrick Alloy led by the new Study In experiments conducted on rats, it has been claimed to be successful in reversing the symptoms of Alzheimer’s. This study was published in the journal Genome Medicine. Study Common drugs used to treat hypertension (high blood pressure) or inflammation (burning or swelling) in humans have been used.
drug effect test
Researchers used a chemical checker to test the ability to reverse the activity of a related protein in the event of disease at the cellular level through drugs already available in the market. Through this tool, the effect of four drugs on different models of mice was investigated. These drugs included two non-steroidal anti-inflammatories and two anti-hypertensive drugs, and all four drugs were successful in inactivating the symptoms of Alzheimer’s in rats.
According to researchers, this result can change the way of treatment. Along with this, the situation or symptoms of different phases of Alzheimer’s will be detected soon. Dr.Patick Alloy (Dr. Patrick Alloy) Said that epidemiological studies also indicated that people who regularly took anti-inflammatory drugs had a lower risk of Alzheimer’s, but it was associated with a specific drug or mechanism. The connection could not be established.
How was the study done?
Dr.Patick Alloy (Dr. Patrick Alloy) For this study led by, researchers divided Alzheimer’s disease into three stages – early, intermediate, and advanced. In each stade, molecular studies of animal behavior, brain effect and gene expression and protein levels were done. Through this method, the researchers compared the relative changes in the progression of the disease in an aging healthy person.
What happened in the study
In this study, it was found that some symptoms in Alzheimer’s match the changes that occur with increasing age, but this disease also produces effects different from aging. Dr.Patick Alloy Said that the reason for this disease is also the accumulation of certain types of proteins. But in some cases, instead of overproduction of this protein, disease occurs due to a defect in the process of its disposal.