New weapon to combat Bacteria : Antibiotic resistant bacteria is causing complications in the treatment of many diseases. This is the reason that many types of medicine developed in the last 50 years are not able to show their full effect. But now to deal with this situation, scientists from Karolinska Institutet, Umea University in Sweden and University of Bonn in Germany have discovered a new group of molecules, in which Has antibacterial properties to kill many antibiotic-resistant bacteria. This discovery could help develop effective antibiotics with minimal side effects. This study is in the science journal ‘PNAS’. published happened. Let us tell you that in the treatment of bacterial diseases, becoming antibiotic resistant / inhibiting bacteria is becoming a serious problem. In such a situation, the search for new antibacterial substances has become a big need.
Most of the antibiotics used in the treatment of diseases work by inhibiting the ability of the bacteria to form the cell wall, thereby triggering the fragmentation of the bacteria. Also known are penicillins, which block the enzyme walling, newer antibiotics such as daptomycin or the more recently developed Teixobactin Lipid-2 bind to specific molecules.
How do bacteria build cell walls?
All bacteria require lipid-2 to form a cell wall. Antibiotics, which bind to the building blocks of this cell wall, are usually very large and complex molecules, so they are very difficult to modify with chemical methods. These molecules are also inactive against a group of disease-causing bacteria. They are surrounded by an additional wall or outer membrane (a type of wall), which prevents the penetration of antibacterial substances.
what the experts say
Professor of the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet Birgitta Henriques Normark “Therefore, new antibiotics try to target lipid-2 the most. We have identified the first microscopic antibacterial compound that binds to lipid molecules. We found in our study that even mutant bacteria do not have resistance to it. It is very encouraging.
How did the study happen?
In this research done at the Karolinska Institutet and Umea University in Sweden, scientists used a large number of chemical compounds on pneumococci that cause pneumonia. Of the few active compounds selected in this way, molecules of the THCZ group were found to bind to lipid-2 and prevent bacteria from forming cell walls. These molecules also inhibit the formation of sugar capsules, which are needed by pneumococci to cause disease by evading the immune system.
According to the researchers, the specialty of this micromolecule is that it can be changed chemically. Therefore, it is expected that through this, THCZ can be replaced, which will increase the antibacterial effect and also reduce its side effect on human cells. Experiments conducted in the lab have found that THz- antibiotic resistant has been effective on many bacteria. This type of experiment has been done on bacteria like MRSA i.e. methicillin-resistant staphylococci, vancomycin-resistant enterococci (VRE) and penicillin-resistant pneumococci (PNSP).
It has also been found to be effective against gonococci that cause gonorrhea and mycobacteria that cause tuberculosis. During the experiment no such bacteria were found that have developed resistant to THCZ. Researchers say that now they are trying to do something so that the THCZ molecule can also penetrate the outer cellular membrane of multi-resistant bacteria.