Required Dose Of Antibiotic : Antibiotics play an important role in preventing or treating any kind of infection that our body may have. But for this, how much dose of antibiotic should be given, it is also necessary. Because low-dose germs are at risk of developing immunity against drugs, while high-dose can cause many other side effects. In this way, if there is information about what level of antibiotic should be, then this problem can be solved to a great extent. According to a report published in Dainik Jagran, in this direction, a team of engineers and biotechnologists from the University of Freiburg, Germany, has demonstrated for the first time that antibiotics can be injected into the body from a breath sample in mammals. level can be measured. This studyadvanced materials‘ has been published in the Journal. It has been told in this that the antibiotic concentration (concentration) in the blood can also be detected through this.
Biosensor made of multiplex chip
It is further written in the report that the team of researchers has built a bio sensor for this, which is made of a multiplex chip and it can test many substances in many samples simultaneously. Researchers claim that this biosensor is based on a synthetic protein, which reacts with antibiotics and produces a change in current.
Equally accurate results on plasma
Researchers say that in the future such a test could be used to determine the dose of antibiotic given to a person to fight the infection. This can reduce the risk of developing resistant strains of bacteria. Researchers have tested this biosensor on blood, plasma, urine, saliva and breath of pigs given antibiotics. Its result was found to be as accurate on plasma as it is in Standard Medical Laboratory Procedures. Whereas before this it was not possible to measure the level of antibiotic from the sample of the exhaled breath.
According to Dr Can Dinser, the head of the research team, so far only the presence of antibiotics could be detected from the breath. But through our microfluidic chip, with synthetic proteins, we can detect even the lowest concentration in the breath and that can be linked with the blood value.
Why is it important to decide the dosage of medicine?
In the treatment of any disease, it is necessary for the doctors to decide the level of antibiotics for a particular person. And it is decided on the basis of the patient’s wound, organ failure or risk of death. The use of antibiotics in small amounts allows the bacteria to mutate, causing the bacteria to develop resistance to the drug and the drug’s effectiveness is reduced.
How does Bio Sensor work?
The protein penicillin present in the Microfluidic Bio Sensor can recognize the beta-lactams of antibiotics. The antibiotic and enzyme-linked beta-lactams in the sample compete to bind to bacterial proteins. This creates a current change like a battery. When there is more antibiotic in the sample, the enzyme product is produced in less quantity, so that the current can be measured. It is a natural receptor protein-based process used by resistant bacteria to detect threats from antibiotics. Researchers say that on the basis of this we can say that we have defeated bacteria in its own game.