This precise method of DBS can be effective in the treatment of Parkinson’s – Research


Treatment of Parkinson Disease : Brain Disorder In Parkinson’s disease, a person has to face difficulties like tremors, stiffness and imbalance in the body in addition to difficulty in walking. Due to Parkinson’s, the patient’s tongue sometimes falters in speaking and hands start trembling when writing. At the same time, problems like change in mental behavior, lack of sleep, depression and memory loss also increase. According to the news published in Dainik Jagran newspaper, now a new hope has arisen for the treatment of Parkinson’s disease. Of America Carnegie Mellon University (CMU)) researchers have found an accurate method of deep brain stimulation (DBS), which may prove to be more effective than any existing therapy. This research is in the Science Journal published happened.

This study by Aryn H. Gittis of CMU’s Gittis Lab and colleagues could prove to be very important in the treatment of Parkinson’s. In this method, an attempt has been made to increase the efficiency of the implanted thin electrodes in the DBS process to send electrical signals to the part of the brain that controls the movement of the body.

what will be the benefit
This can be an effective way to control the unwanted uncontrolled activity of the patient’s body. But for this it is necessary that the patient gets continuous electrical stimulation (stimulation / stimulation or wakefulness). If this stimulus stops, the symptoms appear immediately.

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Aryan H. Gittis, associate professor at CMU’s Mellon College of Science, says that this new research can change the situation. They hope that this new method can reduce the time of stimulation and maintain its effect for a long time, thereby minimizing side effects as well as increasing the battery life of the implants.

What happened in the research
During the research, specific types of neurons were discovered in the motor circuits of the brain, which can provide long-term relief from motor symptoms in Parkinson’s models. GITIS used optogenetics technology in this experiment. However, at present this technique cannot be used on humans. In such a situation, his team is trying to figure out how to use it on Parkinson’s patients. Researchers have succeeded in developing a new DBS protocol on mice, which uses less electrical stimulation.

What’s different in the new protocol
According to Gittis, this is a big progress in the treatment of Parkinson’s. Indeed, in other DBS protocols, symptoms appear immediately as soon as the stimulus is stopped. But in the new protocol, the effect of stimulation lasts at least four times longer. In this protocol, researchers targeted specific types of neurons in the globus pallidus (the area with electrical stimulation) of the brain. Now the effort is to find a way to use it in specific ways. In this sequence, in the study of those cells, it has been found out whether there is something that drives it?

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The lead author of this study, Teresa Spix (TERESA A. SPIX), said that scientists are not yet fully aware of why DBS works. In such a situation, our work was like hitting our hands in the dark. But our shorts burst approach has given great relief from the symptoms of the disease. Some questions have arisen from the experiment, whose answers may help patients in the near future.

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